Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …

Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …

Enhancers are distal regulatory elements that can activate tissue-specific gene expression
and are abundant throughout mammalian genomes. Although substantial progress has …

To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …

In developed countries, the majority of all violent crime is committed by a small group of
antisocial recidivistic offenders, but no genes have been shown to contribute to recidivistic …

Genome-wide association analysis advanced understanding of blood pressure (BP), a
major risk factor for vascular conditions such as coronary heart disease and stroke …

Anhedonia is a cardinal symptom of major depression and is often refractory to standard
treatment, yet no approved medication for this specific symptom exists. In this exploratory re …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Abstract Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of
the cadherin family of cell adhesion molecules, has been identified as a risk gene for …