Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development
The vertebrate lens is a valuable model system for investigating the gene expression
changes that coordinate tissue differentiation due to its inclusion of two spatially separated …
changes that coordinate tissue differentiation due to its inclusion of two spatially separated …
Impact of α-crystallin protein loss on zebrafish lens development
The α-crystallin small heat shock proteins contribute to the transparency and refractive
properties of the vertebrate eye lens and prevent the protein aggregation that would …
properties of the vertebrate eye lens and prevent the protein aggregation that would …
Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages
C Arcanjo, O Armant, M Floriani, I Cavalie, V Camilleri… - Aquatic Toxicology, 2018 - Elsevier
Tritium (3 H) is a radioactive isotope of hydrogen. In the environment, the most common form
of tritium is tritiated water (HTO). The present study aimed to identify early biomarkers of HTO …
of tritium is tritiated water (HTO). The present study aimed to identify early biomarkers of HTO …
The role of a lens survival pathway including sox2 and αA-crystallin in the evolution of cavefish eye degeneration
L Ma, A Parkhurst, WR Jeffery - EvoDevo, 2014 - Springer
Abstract Background The teleost Astyanax mexicanus is a single species consisting of eyed
surface-dwelling (surface fish) and blind cave-dwelling (cavefish) morphs. Cavefish eyes are …
surface-dwelling (surface fish) and blind cave-dwelling (cavefish) morphs. Cavefish eyes are …
Lens defects in Astyanax mexicanus Cavefish: Evolution of crystallins and a role for alphaA‐crystallin
The fish Astyanax mexicanus presents, within the same species, populations of river‐
dwelling surface fish (SF) and blind cave‐living fish. In cavefish (CF), the eyes develop …
dwelling surface fish (SF) and blind cave‐living fish. In cavefish (CF), the eyes develop …
Transient cerebellar alterations during development prior to obvious motor phenotype in a mouse model of spinocerebellar ataxia type 6
Key points Spinocerebellar ataxia type 6 (SCA6) is a midlife‐onset neurodegenerative
disease caused by a CACNA1A mutation; CACNA1A is also implicated in cerebellar …
disease caused by a CACNA1A mutation; CACNA1A is also implicated in cerebellar …
Abnormal retinal development in Cloche mutant zebrafish
S Dhakal, CB Stevens, M Sebbagh… - Developmental …, 2015 - Wiley Online Library
Background: Functions for the early embryonic vasculature in regulating development of
central nervous system tissues, such as the retina, have been suggested by in vitro studies …
central nervous system tissues, such as the retina, have been suggested by in vitro studies …
A conserved role of αA-crystallin in the development of the zebrafish embryonic lens
P Zou, SY Wu, HA Koteiche, S Mishra, DS Levic… - Experimental eye …, 2015 - Elsevier
Abstract αA-and αB-crystallins are small heat shock proteins that bind thermodynamically
destabilized proteins thereby inhibiting their aggregation. Highly expressed in the …
destabilized proteins thereby inhibiting their aggregation. Highly expressed in the …
Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants
SY Wu, P Zou, S Mishra, HS Mchaourab - Plos one, 2018 - journals.plos.org
Mutations in the small heat shock proteins α-crystallins have been linked to autosomal
dominant cataracts in humans. Extensive studies in vitro have revealed a spectrum of …
dominant cataracts in humans. Extensive studies in vitro have revealed a spectrum of …
Why does the zebrafish cloche mutant develop lens cataract?
The zebrafish has become a valuable model for examining ocular lens development,
physiology and disease. The zebrafish cloche mutant, first described for its loss of …
physiology and disease. The zebrafish cloche mutant, first described for its loss of …