The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Hox proteins are well known for executing highly specific functions in vivo, but our
understanding of the molecular mechanisms underlying gene regulation by these …

The skin of the nematode Caenorhabditis elegans is composed of a simple epidermal
epithelium and overlying cuticle. The skin encloses the animal and plays central roles in …

Coordination of inter-tissue stress signaling is essential for organismal fitness. Neuronal
mitochondrial perturbations activate the mitochondrial unfolded-protein response (UPR mt) …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

In various organisms, cells divide asymmetrically to produce distinct daughter cells. In the
nematode Caenorhabditis elegans, asymmetric division is controlled by the asymmetric …

The canonical Wnt/β-catenin pathway is extensively characterized, broadly conserved, and
clinically important. In this review, we describe the C. elegans Wnt/β-catenin asymmetry …

Until a decade ago it was believed that the wall of adult blood vessels exclusively contains
terminally differentiated cell types. A paradigm shift was unavoidable since studies from …

How asymmetric divisions are connected to the terminal differentiation program of neuronal
subtypes is poorly understood. In C. elegans, two homeodomain transcription factors, TTX-3 …

Hematopoietic stem cells in the bone marrow have the capacity to both self-renew and to
generate all cells of the hematopoietic system. The balance of these two activities is …