Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High
morbidity and mortality caused by DM are closely linked to its complications in multiple …

Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at
regions of disturbed blood flow and is triggered by an interplay between endothelial …

The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Atherosclerosis is the primary underlying cause of cardiovascular disease which
preferentially develops at arterial regions exposed to disturbed flow (DF), but much less at …

Different blood flow patterns in the arteries can alter the adaptive phenotype of vascular
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Aims Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and
characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth …