Thymoquinone (TQ) possesses anticonvulsant, antianxiety, antidepressant, and
antipsychotic properties. It could be utilized to treat drug misuse or dependence, and those …

The primary aim of this review is to summarize the literature on natural products that are
effective in the treatment of various neurological disorders by targeting endoplasmic …

Background Epilepsy is one of the most common brain disorder and, despite the possible
use of several therapeutic options, many patients continue to have seizures for their entire …

Dry eye disease (DED) is a common ocular disorder characterized by an inadequate
lubrication of the eye by tears leading to inflammation and the alteration of the ocular …

In the central nervous system, some specific phosphodiesterase (PDE) isoforms modulate
pathways involved in neuronal plasticity. Accumulating evidence suggests that PDE9 may …

Although doxorubicin (DOX) is used in many cancer treatments, it causes neurotoxicity. In
this study, the effect of thymoquinone (THQ), a powerful antioxidant, on DOX‐induced …

Thymoquinone (TQ) is the main constituent of Nigella sativa L. essential oil. In vitro studies
have shown its protective effect against H2O2-induced oxidative stress in human retinal …

Cyclophosphamide (CYP) is an effective anti‐cancer drug that is widely accepted, but it is
not devoid of unintended toxic effects. Gonadal toxicity is reported as one of the side effects …

Currently, living organisms are increasingly exposed to many toxic chemicals in the
environment. These substances pose a threat to human life, other living organisms and …

Introduction Derangement of axonal mitochondrial bioenergetics occurs during progressive
multiple sclerosis (PMS). However, whether this is a delayed epiphenomenon or an early …