Anticancer metallodrugs based on ruthenium and osmium are among the most investigated
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …

Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Numerous biologically active metal complexes are reported for their unique features and
enhanced functions, particularly towards the inhibition of cancer progression. With the …

Abstract Ruthenium (II)-arene RAPTA-type compounds have been extensively explored for
their medicinal properties. Herein a comprehensive review of this class of compounds is …

The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Cisplatin and other platinum compounds have had a huge impact in the treatment of cancers
and are applied in the majority of anticancer chemotherapeutic regimens. The success of …

The study of metal complexes for the treatment of cancer diseases has resulted in the
identification of some unique properties of ruthenium-based compounds. Among these …

Platinum complexes are widely used anticancer drugs. New generations of metal
chemotherapeutics offer the prospect of combating platinum resistance and expanding the …

After nearly 20 years of research on the use of ruthenium in the fight against cancer, only two
Ru (III) coordination complexes have advanced to clinical trials. During this time, the field …