Many common diseases, such as asthma, diabetes or obesity, involve altered interactions
between thousands of genes. High-throughput techniques (omics) allow identification of …

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP
on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was …

The 'precision medicine (systems medicine)'concept promises to achieve a shift to future
healthcare systems with a more proactive and predictive approach to medicine, where the …

This Pulmonary Perspective summarizes the content and main conclusions of an
international workshop on personalized respiratory medicine coorganized by the Barcelona …

Early regulators of disease may increase understanding of disease mechanisms and serve
as markers for presymptomatic diagnosis and treatment. However, early regulators are …

Many patients with common diseases do not respond to treatment. This is a key challenge to
modern health care, which causes both suffering and enormous costs. One important reason …

In systems biology, researchers aim to understand complex biological systems as a whole,
which is often achieved by mathematical modelling and the analyses of high-throughput …

Introduction: Severe therapy-resistant asthma is an area where there has been recent
advances in understanding that is percolating into improvements in management. Areas …

Severe therapy-resistant asthma has been defined as “asthma which requires treatment with
high dose inhaled corticosteroids (ICSs) plus a second controller (and/or systemic …

Background Systems medicine has become a key word in biomedical research. Although it
is often referred to as P4-(predictive, preventive, personalized and participatory)-medicine, it …