The complement system is increasingly recognized as important in the pathogenesis of
tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement …

The complement system is an essential component of innate immunity that has been more
recently recognized as an unexpected player in various pathological states. These include …

The complement system is implicated in promoting acute secondary injury after traumatic
brain injury (TBI), but its role in chronic post-traumatic neuropathology remains unclear …

The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

Neuromyelitis optica (NMO) is an autoimmune inflammatory disease of the central nervous
system (CNS) characterized by transverse myelitis and optic neuritis. The pathogenic serum …

Dysregulation of the complement system is implicated in neurodegeneration, including
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …

purpose. Polymorphisms in factor H (fH), an inhibitor of the alternative pathway (AP) of
complement activation, are associated with increased risk for age-related macular …

Previous studies indicate a pivotal role for complement in mediating both local and remote
injury following ischemia and reperfusion of the intestine. Here, we report on the use of a …

To selectively modulate human complement alternative pathway (CAP) activity implicated in
a wide range of acute and chronic inflammatory conditions and to provide local cell surface …

Traumatic brain injury (TBI) can result in progressive cognitive decline occurring for years
after the initial insult, and for which there is currently no pharmacological treatment. An …