In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

Abstract Cancer Stem Cells (CSCs) are now considered the primary" seeds" for the onset,
development, metastasis, and recurrence of tumors. Despite therapeutic breakthroughs …

Cancer stem cells (CSCs), with their self-renewal ability and multilineage differentiation
potential, are a critical subpopulation of tumor cells that can drive tumor initiation, growth …

Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

One of the most ancient and highly conserved microRNAs (miRNAs), the let-7 family, has
gained notoriety owing to its regulation of stem cell differentiation and essential role in …

RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-
transcriptional regulators of gene expression, and their aberrant expression contributes to …

Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Abstract OCT4 (POU5F1) is a major regulator of cell pluripotency and plays an important
role not only during embryogenesis but also in tumorigenesis. It has been studied in various …

Mesenchymal stem cells (MSC) display tumor tropism and have been addressed as vehicles
for delivery of anti-cancer agents. As cellular components of the tumor microenvironment …

Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do
not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of …