Detection of multiplex exosomal miRNAs for clinically accurate diagnosis of Alzheimer's disease using label-free plasmonic biosensor based on DNA-Assembled …

S Song, JU Lee, MJ Jeon, S Kim, SJ Sim - Biosensors and Bioelectronics, 2022 - Elsevier
Abstract Alzheimer's disease (AD), the most common neurologic disorder, is characterized
by progressive cognitive impairment. However, the low clinical significance of the currently …

A shape-code nanoplasmonic biosensor for multiplex detection of Alzheimer's disease biomarkers

H Kim, JU Lee, S Song, S Kim, SJ Sim - Biosensors and Bioelectronics, 2018 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease associated with the loss of nerve
cells in the brain. The disease is affected by multifactorial pathways and leads to changes in …

Recent Advances in DNA-assembled Plasmonic Nanoarchitectures for Biomedical Applications

S Song, MJ Jeon, JU Lee, SJ Sim - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
DNA nanotechnology is driven by the precision and programmable properties of DNA, which
serves as a reliable template to guide the self-assembly of various materials, such as metal …

A label-free, ultra-highly sensitive and multiplexed SERS nanoplasmonic biosensor for miRNA detection using a head-flocked gold nanopillar

WH Kim, JU Lee, S Song, S Kim, YJ Choi, SJ Sim - Analyst, 2019 - pubs.rsc.org
Cell-free micro-ribonucleic acids (cf-miRNAs) regulate most human genes by controlling the
mRNA translation and have been considered as the most promising biomarkers for cancer …

Precise profiling of exosomal biomarkers via programmable curved plasmonic nanoarchitecture-based biosensor for clinical diagnosis of Alzheimer's disease

S Song, JU Lee, MJ Jeon, S Kim, CN Lee… - Biosensors and …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease of complex pathogenesis, with
overt symptoms following disease progression. Early AD diagnosis is challenging due to the …

Single plasmonic nanostructures for biomedical diagnosis

X Ma, SJ Sim - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
The field of single nanoparticle plasmonics has grown enormously. There is no doubt that a
wide diversity of the nanoplasmonic techniques and nanostructures represents a …

Self‐Confined Dewetting Mechanism in Wafer‐Scale Patterning of Gold Nanoparticle Arrays with Strong Surface Lattice Resonance for Plasmonic Sensing

Z Chen, A Cao, D Liu, Z Zhu, F Yang, Y Fan… - Advanced …, 2024 - Wiley Online Library
A self‐confined solid‐state dewetting mechanism is reported that can fundamentally reduce
the use of sophisticated nanofabrication techniques, enabling efficient wafer‐scale …

Real-time monitoring of distinct binding kinetics of hot-spot mutant p53 protein in human cancer cells using an individual nanorod-based plasmonic biosensor

S Song, JU Lee, J Kang, KH Park, SJ Sim - Sensors and Actuators B …, 2020 - Elsevier
Hot-spot mutant p53 proteins are highly associated with cancer malignancy and
chemotherapy resistance of various cancers. Precise detection of the hot-spot mutant protein …

Surface plasmon resonance sensing: from purified biomolecules to intact cells

Y Su, W Wang - Analytical and bioanalytical chemistry, 2018 - Springer
Surface plasmon resonance (SPR) has become a well-recognized label-free technique for
measuring the binding kinetics between biomolecules since the invention of the first SPR …

Plasmonic Sensors for Applications in Liquid Biopsies

JU Lee, SJ Sim - … -edge Technologies in Biological Sensing and …, 2023 - taylorfrancis.com
A liquid biopsy is a non-invasive means of gaining insights into the dynamics of disease
using a patient's body fluids of patients. It has recently attracted much interest in cancer …