Integrin signalling in joint development, homeostasis and osteoarthritis
Integrins are key regulators of cell–matrix interactions during joint development and joint
tissue homeostasis, as well as in the development of osteoarthritis (OA). The signalling …
tissue homeostasis, as well as in the development of osteoarthritis (OA). The signalling …
RNA Sequencing in Disease Diagnosis
C Smail, SB Montgomery - Annual Review of Genomics and …, 2024 - annualreviews.org
RNA sequencing (RNA-seq) enables the accurate measurement of multiple transcriptomic
phenotypes for modeling the impacts of disease variants. Advances in technologies …
phenotypes for modeling the impacts of disease variants. Advances in technologies …
Linking Genome-Wide Association Studies to Pharmacological Treatments for Psychiatric Disorders
Importance Large-scale genome-wide association studies (GWAS) should ideally inform the
development of pharmacological treatments, but whether GWAS-identified mechanisms of …
development of pharmacological treatments, but whether GWAS-identified mechanisms of …
Genomic strategies for drug repurposing
Functional genomics, a multidisciplinary subject, investigates the functions of genes and
their products in biological systems to better understand diseases and find new drugs. Drug …
their products in biological systems to better understand diseases and find new drugs. Drug …
Synergizing drug repurposing and target identification for neurodegenerative diseases.
M Sahu, S Vashishth, N Kukreti, A Gulia… - Progress in Molecular …, 2024 - europepmc.org
Despite dedicated research efforts, the absence of disease-curing remedies for
neurodegenerative diseases (NDDs) continues to jeopardize human society and stands as …
neurodegenerative diseases (NDDs) continues to jeopardize human society and stands as …
Genomic Approaches for Drug Repurposing
Functional genomics, a multidisciplinary subject, investigates the functions of genes and
their products in biological systems to better understand diseases and find new drugs. Drug …
their products in biological systems to better understand diseases and find new drugs. Drug …
Linking GWAS to pharmacological treatments for psychiatric disorders
Importance Large-scale genome-wide association studies (GWASs) are expected to inform
the development of pharmacological treatments, however the mechanisms of …
the development of pharmacological treatments, however the mechanisms of …