Oxadiazole: A highly versatile scaffold in drug discovery

N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

A first-principles evaluation on the interaction of 1, 3, 4-oxadiazole with pristine and B-, Al-, Ga-doped C60 fullerenes

İ Muz, M Kurban - Journal of Molecular Liquids, 2021 - Elsevier
In this study, the interaction of 1, 3, 4-oxadiazole with pristine and B-, Al-, Ga-doped C 60
fullerenes were examined by density functional theory (DFT) for the first time. The results …

Isolation of potassium salt of oxadiazole-2-thione and in vitro anticancer activities of its Cu (II) and Zn (II) complexes against MDA-MB-231 human breast carcinoma …

MK Gond, N Rai, B Chandra, V Gautam, S Garai… - Dalton …, 2023 - pubs.rsc.org
A potassium 4-(pyridyl)-1, 3, 4-oxadiazole-2-thione was isolated in a basic medium, and its
complexes [Cu (en) 2 (pot) 2](1) and [Zn (en) 2 (pot) 2] HBrĚCH3OH (2) containing …

Calcium and magnesium silicate hydrates formed in the presence of sodium hydroxide: Insight from experiments and DFT simulation

J Li, Y Nong, S Yin, Z Chen, T Su, Q Yu - Materials Today Communications, 2022 - Elsevier
In this paper, calcium and magnesium silicate hydrates were synthesized in the presence of
sodium hydroxide to explore the effect of alkaline environment on the structure of synthetic …

A combined crystallographic and theoretical investigation of noncovalent interactions in 1, 3, 4-oxadiazole-2-thione-N-Mannich derivatives: in vitro bioactivity and …

LH Al-Wahaibi, K Alagappan, RM Gomila, O Blacque… - RSC …, 2023 - pubs.rsc.org
Two 1, 3, 4-oxadiazole-2-thione-N-Mannich derivatives, specifically 5-(4-chlorophenyl)-3-[(2-
trifluoromethylphenylamino) methyl]-1, 3, 4-oxadiazole-2 (3H)-thione (1) and 5-(4 …

Recent Updates on Interaction Studies and Drug Delivery of Antimalarials with Serum Albumin proteins

K Azeem, I Irfan, Q Rashid, S Singh… - Current Medicinal …, 2024 - ingentaconnect.com
This review focuses on recent trends in the binding study of various antimalarial agents with
serum albumins in detail. Serum albumin has a significant role in the transport of drugs and …

Quantitative assessment of the nature of noncovalent interactions in N-substituted-5-(adamantan-1-yl)-1, 3, 4-thiadiazole-2-amines: Insights from crystallographic and …

AA El-Emam, ES Kumar, K Janani, LH Al-Wahaibi… - RSC …, 2020 - pubs.rsc.org
Three adamantane-1, 3, 4-thiadiazole hybrid derivatives namely; N-ethyl-5-(adamantan-1-
yl)-1, 3, 4-thiadiazole-2-amine I, N-(4-fluorophenyl)-5-(adamantan-1-yl)-1, 3, 4-thiadiazole-2 …

Mn (II) assisted synthesis of N-phenyl-5-(pyridin-3-yl)-1, 3, 4-oxadiazol-2-amine and evaluation of its antiproliferative activity

S Jaiswal, SK Pandey, T Minocha, S Chandra… - Journal of Molecular …, 2023 - Elsevier
The global burden of cervical cancer is continuously increasing day by day affecting the
world population. Wide arrays of agents are prevalent for the treatment of this chronic …

Antimalarial activity of novel class of 1, 3‐benzoxaborole derivatives containing 1, 3, 4‐oxadiazole moiety

V Adimule, AH Jagadeesha Gowda… - … for Malaria: Novel …, 2022 - Wiley Online Library
In the present research, series of 1, 3‐bezoxoborole containing 1, 3, 4‐oxadiazole
compounds was designed and synthesised by microwave cyclisation (MWC) using 1, 3 …

Novel 1, 3, 4-oxadiazole linked benzopyrimidinones conjugates: Synthesis, DFT study and antimicrobial evaluation

S Chortani, H Edziri, M Manachou… - Journal of Molecular …, 2020 - Elsevier
This work describes the synthesis, characterization and antimicrobial evaluation of a series
of new 1, 3, 4-oxadiazole linked benzopyrimidinones. Their structures were confirmed on the …