Integrating transcriptome and proteome profiling: Strategies and applications
Discovering the gene expression signature associated with a cellular state is one of the
basic quests in majority of biological studies. For most of the clinical and cellular …
basic quests in majority of biological studies. For most of the clinical and cellular …
Transcriptional regulation of inflammasomes
M Cornut, E Bourdonnay, T Henry - International journal of molecular …, 2020 - mdpi.com
Inflammasomes are multimolecular complexes with potent inflammatory activity. As such,
their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this …
their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this …
Methods, tools and current perspectives in proteogenomics
With combined technological advancements in high-throughput next-generation sequencing
and deep mass spectrometry-based proteomics, proteogenomics, ie the integrative analysis …
and deep mass spectrometry-based proteomics, proteogenomics, ie the integrative analysis …
Improved methods for RNAseq-based alternative splicing analysis
The robust detection of disease-associated splice events from RNAseq data is challenging
due to the potential confounding effect of gene expression levels and the often limited …
due to the potential confounding effect of gene expression levels and the often limited …
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: Dynamic profiles from Alpha to Omicron
The ongoing SARS-CoV-2 evolution process has generated several variants due to its
continuous mutations, making pandemics more critical. The present study illustrates SARS …
continuous mutations, making pandemics more critical. The present study illustrates SARS …
Key FAD2, FAD3, and SAD Genes Involved in the Fatty Acid Synthesis in Flax Identified Based on Genomic and Transcriptomic Data
EM Dvorianinova, OL Zinovieva, EN Pushkova… - International journal of …, 2023 - mdpi.com
FAD (fatty acid desaturase) and SAD (stearoyl-ACP desaturase) genes play key roles in the
synthesis of fatty acids (FA) and determination of oil composition in flax (Linum usitatissimum …
synthesis of fatty acids (FA) and determination of oil composition in flax (Linum usitatissimum …
Bottom-up proteomics (2013–2015): keeping up in the era of systems biology
Over 17,000 papers related to proteomics have been published since our 2011− 2013
review. A subset are true gems reporting amazing applications of proteomics to better …
review. A subset are true gems reporting amazing applications of proteomics to better …
Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines
Background Onco-proteogenomics aims to understand how changes in a cancer's genome
influences its proteome. One challenge in integrating these molecular data is the …
influences its proteome. One challenge in integrating these molecular data is the …
[HTML][HTML] Transforming clinical research: The power of high-throughput omics integration
R Vitorino - Proteomes, 2024 - mdpi.com
High-throughput omics technologies have dramatically changed biological research,
providing unprecedented insights into the complexity of living systems. This review presents …
providing unprecedented insights into the complexity of living systems. This review presents …
[HTML][HTML] Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster
OG Zatsepina, EA Nikitina, VY Shilova… - Cell Stress and …, 2021 - Elsevier
Heat shock proteins, in particular Hsp70, play a central role in proteostasis in eukaryotic
cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress …
cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress …