The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to
unravel structure, function and regulation of protease expression, maturation and activity. In …

Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase'(ADAM) family,
controls vital cellular functions through cleavage of transmembrane substrates. Here we …

In contrast to many other signalling mechanisms shedding of membrane-anchored proteins
is an irreversible process. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the …

A disintegrin and metalloproteases (ADAMs) are key mediators of cell signaling by
ectodomain shedding of various growth factors, cytokines, receptors and adhesion …

Several membrane-bound proteins with a single transmembrane domain are subjected to
limited proteolysis at the cell surface. This cleavage leads to the release of their biologically …

The discovery of the disintegrin and metalloproteinase 17 (ADAM17), originally identified as
tumor necrosis factor-a converting enzyme (TACE) for its ability as sheddase of TNF-α …

By mediating proteolytic shedding on the cell surface the disintegrin and metalloproteinases
ADAM10 and ADAM17 function as critical regulators of growth factors, cytokines and …

Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares
the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other …

Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and
robust manner during infection. A cascade of adhesion events direct their attachment to the …