Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology.
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …

Maintaining the structure of protein and peptide drugs has become one of the most important
goals of scientists in recent decades. Cold and thermal denaturation conditions …

Background Long non-coding RNA nuclear paraspeckle assembly transcript 1 (lncRNA
NEAT1) was found to be closely related to the pathological changes in brain and nervous …

The accumulation and misfolding of α‐synuclein (α‐syn) represent the main pathological
hallmark of PD. Overexpression of α‐syn and failure of cellular protein degradation systems …

Autophagy is a ubiquitous cellular catabolic process responsive to energy stress. Research
over the past decade has revealed that cardiomyocyte autophagy is a prominent …

Tau aggregates propagate in brain cells and transmit to neighboring cells as well as
anatomically connected brain regions by prion-like mechanisms. Soluble tau aggregates …