Viruses exploit the translation machinery of an infected cell to synthesize their proteins.
Therefore, viral mRNAs have to compete for ribosomes and translation factors with cellular …

Although viruses require cellular functions to replicate, their absolute dependence upon the
host translation machinery to produce polypeptides indispensable for their reproduction is …

Directed evolution, artificial selection toward designed objectives, is routinely used to
develop new molecular tools and therapeutics. Successful directed molecular evolution …

RNA is a central molecule for viruses; however, the interactions that viral RNA (vRNA)
establishes with the host cell is only starting to be elucidated. Here, we determine the …

At the forefront of vector control efforts are strategies that leverage host-microbe associations
to reduce vectorial capacity. The most promising of these efforts employs Wolbachia, a …

Upon oxidative stress, mammalian cells rapidly reprogram their translation. This is
accompanied by the formation of stress granules (SGs), cytoplasmic ribonucleoprotein …

The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus
infection has been known for decades. However, most of the studies characterizing this …

Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading
frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral …

Silvestrol, a natural compound that is isolated from plants of the genus Aglaia, is a specific
inhibitor of the RNA helicase eIF4A, which unwinds RNA secondary structures in 5 …

Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and
encephalitis in humans. Since the role of cellular kinases in alphavirus replication is …