Natural and targeted circuit reorganization after spinal cord injury

MA Anderson, JW Squair, M Gautier, TH Hutson… - Nature …, 2022 - nature.com
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Bioelectronic medicine: preclinical insights and clinical advances

VA Pavlov, KJ Tracey - Neuron, 2022 - cell.com
The nervous system maintains homeostasis and health. Homeostatic disruptions underlying
the pathobiology of many diseases can be controlled by bioelectronic devices targeting CNS …

[HTML][HTML] Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

S Bowles, J Hickman, X Peng, WR Williamson… - Neuron, 2022 - cell.com
Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury

BA Karamian, N Siegel, B Nourie, MD Serruya… - Journal of Orthopaedics …, 2022 - Springer
Electrical stimulation is used to elicit muscle contraction and can be utilized for
neurorehabilitation following spinal cord injury when paired with voluntary motor training …

Targeted vagus nerve stimulation for rehabilitation after stroke

ND Engineer, TJ Kimberley, CN Prudente… - Frontiers in …, 2019 - frontiersin.org
Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals,
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …

Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury

PG Nagappan, H Chen, DY Wang - Military Medical Research, 2020 - Springer
Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …

Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

DR Hulsey, CM Shedd, SF Sarker, MP Kilgard… - Experimental …, 2019 - Elsevier
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific
reorganization of movement representations in the motor cortex. This effect is hypothesized …

[HTML][HTML] How to fail with paired VNS therapy

SA Hays, RL Rennaker II, MP Kilgard - Brain stimulation, 2023 - Elsevier
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic
therapy. In particular, the delivery of VNS paired with training to promote neural changes has …

A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation

A Evancho, WJ Tyler, K McGregor - Frontiers in human neuroscience, 2023 - frontiersin.org
Rehabilitation approaches for individuals with neurologic conditions have increasingly
shifted toward promoting neuroplasticity for enhanced recovery and restoration of function …

Vagus nerve stimulation reduces neuroinflammation through microglia polarization regulation to improve functional recovery after spinal cord injury

H Chen, Z Feng, L Min, W Deng, M Tan… - Frontiers in …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a devastating disease that lacks effective treatment.
Interestingly, recent studies indicated that vagus nerve stimulation (VNS), neuromodulation …