In certain unique clinical settings, the ability of the antimicrobial agent administered to kill the
pathogen outright may be quite important. These situations invariably involve infection of a …

Chronic osteomyelitis has been a difficult problem for patients and the treating physicians.
Appropriate antibiotic therapy is necessary to arrest osteomyelitis along with adequate …

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Three separate single-dose studies were performed to define the disposition and
pharmacokinetics of daptomycin in healthy volunteers. Daptomycin was administered as a …

Serial isolates of Staphylococcus aureus showing two-to eightfold increases in teicoplanin
minimum inhibitory concentrations (MICs) and twofold or less increases in MICs of other …

The influence of dosing intervals on the activity of gentamicin and ticarcillin against
Pseudomonas aeruginosa was studied in vivo. Granulocytopenic mice infected with P …

Clinical trials with daptomycin were halted in December 1990 because of treatment failures
including two resistant Staphylococcus aureus strains. High protein binding of daptomycin (> …

Standard minimum inhibitory and bactericidal concentrations are not established for most
antimicrobial agents against strains of bacteria commonly used for quality control in …

The in vitro and in vivo antibacterial activity of A-56268 (TE-031), the 6-O-methyl derivative
of erythromycin, was compared with those of erythromycin and other reference drugs. A …

Objectives To study the possible therapeutic utility of microcin J25 (MccJ25), a peptide RNA
polymerase inhibitor. Methods We subjected the antibiotic to two types of assays. First, with …