Nervous system processes, including cognition and affective state, fundamentally rely on
mitochondria. Impaired mitochondrial function is evident in major depressive disorder …

More than 300 million people suffer from depressive disorders globally. People under early-
life stress (ELS) are reportedly vulnerable to depression in their adulthood, and synaptic …

Background The chronic unpredictable mild stress (CUMS) model has long been
considered the best model for exploring the pathophysiological mechanisms underlying …

The causes of depression are complex, and the current diagnosis methods rely solely on
psychiatric evaluations with no incorporation of laboratory biomarkers in clinical practices …

This revised third edition provides an up to date, comprehensive overview of the field of
comparative psychology, integrating both evolutionary and developmental studies of brain …

Depression is a major cause of disease burden and severely impairs well-being of patients
around the globe. Geniposide (GP) has been revealed to play a significant role in …

Introduction Axonal transport deficit is a key mechanism involved in neurodegenerative
conditions. Fluoxetine, a commonly used antidepressant for treatment of depression, is …

Mesolimbic dopamine (DA) system lesion plays a key role in the pathophysiology of
depression, and our previous study demonstrated that reduced microtubule (MT) stability …

Stress is an important initiating factor in promoting Alzheimer's disease (AD) pathogenesis.
However, the mechanism by which stress induces AD-like cognitive impairment remains to …

Major depressive disorder (MDD) is a debilitating mental disorder with a high prevalence
and severe impacts on quality of life. However, the pathophysiological mechanisms …