Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions
Z Xiang, H Guan, X Zhao, Q Xie, Z Xie, F Cai… - Food Research …, 2024 - Elsevier
Gallic acid (GA), a dietary phenolic acid with potent antioxidant activity, is widely distributed
in edible plants. GA has been applied in the food industry as an antimicrobial agent, food …
in edible plants. GA has been applied in the food industry as an antimicrobial agent, food …
PGRMC1: an enigmatic heme-binding protein
MR McGuire, PJ Espenshade - Pharmacology & therapeutics, 2023 - Elsevier
Abstract Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding
protein that has been implicated in a wide range of cell and tissue functions, including …
protein that has been implicated in a wide range of cell and tissue functions, including …
Impact of pharmacogenomics in clinical practice
N Principi, K Petropulacos, S Esposito - Pharmaceuticals, 2023 - mdpi.com
Polymorphisms of genes encoding drug metabolizing enzymes and transporters can
significantly modify pharmacokinetics, and this can be associated with significant differences …
significantly modify pharmacokinetics, and this can be associated with significant differences …
Microbial metabolism marvels: a comprehensive review of microbial drug transformation capabilities
F Martinelli, I Thiele - Gut Microbes, 2024 - Taylor & Francis
This comprehensive review elucidates the pivotal role of microbes in drug metabolism,
synthesizing insights from an exhaustive analysis of over two hundred papers. Employing a …
synthesizing insights from an exhaustive analysis of over two hundred papers. Employing a …
Mirvetuximab soravtansine in ovarian cancer therapy: expert opinion on pharmacological considerations
CK Nwabufo - Cancer Chemotherapy and Pharmacology, 2024 - Springer
ImmunoGen developed mirvetuximab soravtansine as an antibody–drug conjugate
comprising of a humanized anti-folate receptor—α (FRα) monoclonal antibody of IgG1 k …
comprising of a humanized anti-folate receptor—α (FRα) monoclonal antibody of IgG1 k …
Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens
Over 20% of US Food and Drug Administration (FDA)‐approved drugs in the United States
are metabolized by the hepatic enzyme cytochrome P450 2D6 (CYP2D6). The gene …
are metabolized by the hepatic enzyme cytochrome P450 2D6 (CYP2D6). The gene …
Effects of the chemosensitizer verapamil on P-glycoprotein substrate efflux in rainbow trout hepatocytes
CU Johnston, CJ Kennedy - … and Physiology Part C: Toxicology & …, 2024 - Elsevier
The ATP-dependent membrane transporter P-glycoprotein (P-gp) is associated with
resistance to a wide variety of chemical substrates, as well as the multi-drug resistance …
resistance to a wide variety of chemical substrates, as well as the multi-drug resistance …
Using population pharmacokinetic analyses of drugs metabolized by CYP2D6 to study the genotype–phenotype translation
T Frederiksen - Basic & Clinical Pharmacology & Toxicology, 2023 - Wiley Online Library
Abstract Cytochrome P450 2D6 (CYP2D6) is an important drug‐metabolizing enzyme
exhibiting extensive interindividual variability predominantly caused by genetic …
exhibiting extensive interindividual variability predominantly caused by genetic …
Differences in constitutive gene expression of cytochrome P450 enzymes and ATP-binding cassette transporter gene expression between a susceptible and a highly …
N Jakobs, S Andreotti, S Ramünke… - Parasites & vectors, 2024 - Springer
Anthelmintic resistance in ruminants is a widespread problem that has a severe impact on
productivity and animal welfare. The helminth Haemonchus contortus is generally …
productivity and animal welfare. The helminth Haemonchus contortus is generally …
Evaluating the Therapeutic Potential of Curcumin and Synthetic Derivatives: A Computational Approach to Anti-Obesity Treatments
MT Moetlediwa, BU Jack, SE Mazibuko-Mbeje… - International Journal of …, 2024 - mdpi.com
Natural compounds such as curcumin, a polyphenolic compound derived from the rhizome
of turmeric, have gathered remarkable scientific interest due to their diverse metabolic …
of turmeric, have gathered remarkable scientific interest due to their diverse metabolic …