Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

The postsynaptic density (PSD)-95 family of membrane-associated guanylate kinases
(MAGUKs) are major scaffolding proteins at the PSD in glutamatergic excitatory synapses …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism
requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major …

G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …

▪ Abstract PDZ domains are modular protein interaction domains that bind in a sequence-
specific fashion to short C-terminal peptides or internal peptides that fold in a β-finger. The …

Protein S-palmitoylation, the covalent lipid modification of the side chain of Cys residues
with the 16-carbon fatty acid palmitate, is the most common acylation of proteins in …

Increasing evidence suggests that biological membranes can be laterally subdivided into
domains enriched in specific lipid and protein components and that these domains may be …