A comprehensive understanding of transcription factor binding sites (TFBSs) is a key
problem in contemporary biology, which is a critical issue in gene regulation. Identifying a …

DNA sequence specificity refers to the ability of DNA sequences to bind specific proteins.
These proteins play a central role in gene regulation such as transcription and alternative …

Background The notion of DNA motif is a mathematical abstraction used to model regions of
the DNA (known as Transcription Factor Binding Sites, or TFBSs) that are bound by a given …

In the gene expression process, a transcription factor molecule will bind to a short substring
in the promoter region of a gene in order to start the transcription process. This short …

The motif discovery problem consists of uncovering exceptional patterns (called motifs) in
sets of sequences. It arises in molecular biology when searching for yet unknown functional …

In this study, a new genetic algorithm was developed to discover the best motifs in a set of
DNA sequences. The main steps were: finding the potential positions in each sequence by …

Optimal alignment of structured motifs, where the gaps between the motif boxes have known
positions and known minimum and maximum sizes, is an important problem. The well …

A simple motif is a short DNA sequence found in the promoter region and believed to act as
a binding site for a transcription factor protein. A structured motif is a sequence of simple …

Controlling the differential expression of many thousands different genes at any given time is
a fundamental task of metazoan organisms and this complex orchestration is controlled by …

Background The notion of DNA motif is a mathematical abstraction used to model regions of
the DNA (known as Transcription Factor Binding Sites, or TFBSs) that are bound by a given …