Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Mesocorticolimbic circuit mechanisms of social dominance behavior

TY Choi, S Jeong, JW Koo - Experimental & Molecular Medicine, 2024 - nature.com
Social animals, including rodents, primates, and humans, partake in competition for finite
resources, thereby establishing social hierarchies wherein an individual's social standing …

Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice

JH Kim, N Michiko, IS Choi, Y Kim, JY Jeong… - Plos …, 2024 - journals.plos.org
Reactive astrocytes are associated with neuroinflammation and cognitive decline in diverse
neuropathologies; however, the underlying mechanisms are unclear. We used optogenetic …

Astrocytes as a mechanism for contextually-guided network dynamics and function

L Gong, F Pasqualetti, T Papouin… - PLOS Computational …, 2024 - journals.plos.org
Astrocytes are a ubiquitous and enigmatic type of non-neuronal cell and are found in the
brain of all vertebrates. While traditionally viewed as being supportive of neurons, it is …

Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC

LS Zhu, C Lai, CW Zhou, HY Chen, ZQ Liu, Z Guo… - Cell Discovery, 2024 - nature.com
Individuals' continuous success in competitive interactions with conspecifics strongly affects
their social hierarchy. Medial prefrontal cortex (mPFC) is the key brain region mediating both …

Astrocytes as a mechanism for meta-plasticity and contextually-guided network function

L Gong, F Pasqualetti, T Papouin, SN Ching - arXiv preprint arXiv …, 2023 - arxiv.org
Astrocytes are a highly expressed and highly enigmatic cell-type in the mammalian brain.
Traditionally viewed as a mediator of basic physiological sustenance, it is increasingly …

Acetylcholine muscarinic M1 receptors in the rodent prefrontal cortex modulate cognitive abilities to establish social hierarchy

WJ Chen, H Chen, ZM Li, WY Huang… - …, 2024 - nature.com
In most social species, the attainment of social dominance is strongly affected by personality
traits. Dominant individuals show better cognitive abilities, however, whether an individual's …

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

N Villalobos - International Journal of Molecular Sciences, 2024 - mdpi.com
Network dynamics are crucial for action and sensation. Changes in synaptic physiology lead
to the reorganization of local microcircuits. Consequently, the functional state of the network …

Neuroligin1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures

H Zhang, Y Niu, P Yuan, W Liu, W Zhu, J Sun - Experimental Neurology, 2024 - Elsevier
Background Repeated sevoflurane exposures in neonatal rats may lead to neuronal
apoptosis affecting long-term cognitive function, the mechanism is unknown. Neuroligin1 …

Prefrontocortical Astrocytes Regulate Dominance Hierarchy in Male Mice

Y Tang, HY Yin, P Illes - Neuroscience Bulletin, 2024 - Springer
Accepted: 28 September 2023© Center for Excellence in Brain Science and Intelligence
Technology, Chinese Academy of Sciences 2023 of the genetically encoded Ca2+-indicator …