Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …

Historically women were frequently excluded from clinical trials and drug usage to protect
unborn babies from potential harm. As a consequence, the impact of sex and gender on …

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are
phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most …

Basal-like breast cancers form a distinct subtype of breast cancer characterized by the
expression of markers expressed in normal basal/myoepithelial cells. Breast cancers arising …

Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome
inactivation (XCI) in early embryogenesis, is a common feature of breast cancer (BC) …

With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC)
have generated enormous interest as agents of cell replacement therapy. One potential …

Long noncoding RNAs (lncRNAs) have emerged as important modulators of a wide range of
biological processes in normal and disease states. In particular, lncRNAs have garnered …

Disappearance of the Barr body is considered a hallmark of cancer, although whether this
corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is …