The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated
protein kinase pathway. Hyperactivation of RAF proteins, particularly BRAF and CRAF …

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly
dysregulated in human malignancies by processes driven by RAS or RAF oncogenes …

Pancreatic cancer is an aggressive malignancy with increasing incidence. Pancreatic ductal
adenocarcinoma (PDAC) accounts for> 90% of pancreatic cancer diagnoses, while other …

Gene fusions and rearrangements play a crucial role in tumor biology. They are rare events
typically detected in KRAS wild-type (WT) pancreatic tumors. Their identification can inform …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with a 5-year overall
survival of 11%. The disease is usually diagnosed at advanced stages, and systemic …

Pancreatic cancer is one of the deadliest malignancies in humans and it is expected to play
a bigger part in cancer burden in the years to come. Pancreatic ductal adenocarcinoma …

Pancreatic acinar cell carcinoma (PACC) is a rare form of pancreatic cancer that commonly
harbors targetable alterations, including activating fusions in the MAPK pathway and loss-of …

Most available molecular data on pancreatic acinar cell carcinoma (PACC) are provided by
studies of adult cases. BRAF, RAF1, or RET rearrangements have been described in …

Context.—Comprehensive genomic profiling has demonstrated that approximately 20% of
pancreatic carcinomas with acinar differentiation harbor potentially targetable BRAF fusions …

The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G
protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen …