Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report …

Stem cells are imbued with unique qualities. They have the capacity to propagate
themselves through symmetric divisions and to divide asymmetrically to engender new cells …

Background & Aims Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) both exhibit
notable cancer stem cell (CSC) features. Moreover, the development of both diseases is …

Tissue regeneration requires inflammatory and reparatory activity of macrophages.
Macrophages detect and eliminate the damaged tissue and subsequently promote …

Cardiac hypertrophy in response to chronic pathological stress is a common feature
occurring with many forms of heart disease. This pathological hypertrophic growth increases …

Glial cells expressing neuron‐glial antigen 2 (NG2), also known as oligodendrocyte
progenitor cells (OPCs), play a critical role in maintaining brain health. However, their ability …

Duchenne muscular dystrophy (DMD) affects myofibers and muscle stem cells, causing
progressive muscle degeneration and repair defects. It was unknown whether dystrophic …

Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused
by lack of the cytoskeletal protein dystrophin. There is currently no cure for DMD although …

Regulation of mRNA splicing, processing and stability is increasingly recognized as a critical
control point in dynamically altering gene expression during stress or disease. Very little is …