The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Covering: 2000 to 2023 This review presents the exceptional story of ophiobolin A (OphA)
and sphaeropsidin A (SphA), a sesterterpene and a diterpene, respectively, which were …

Complex multicellular organisms are composed of distinct tissues involving specialized cells
that can perform specific functions, making such life forms possible. Species are defined by …

Covering: up to June 2017 Natural products and endogenous metabolites engage specific
targets within tissues and cells through complex mechanisms. This review examines the …

The current study represents the first comprehensive investigation into the general
antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have …

Traditional lung cancer treatments involve chemical or radiation therapies after surgical
tumor removal; however, these procedures often kill normal cells as well. Recent studies …

Background Surgery combined with chemotherapy is an important therapy for non-small cell
lung cancer (NSCLC). However, chemotherapy drug resistance seriously hinders the …

Drimane and coloratane sesquiterpenoids are present in several plants, microorganisms,
and marine life. Because of their cytotoxic activity, these sesquiterpenoids have received …

In a search of small molecules active against apoptosis-resistant cancer cells, including
glioma, melanoma, and non-small cell lung cancer, we previously prepared α, β-and γ, δ …

Prostate cancer (PCa) is the second leading cause of death in American men. The
chemotherapeutic treatment strategies are generally not effective and can lead to side …