Spatial learning impairments and discoordination of entorhinal‐hippocampal circuit coding following prolonged febrile seizures

ML Kloc, Y Chen, JM Daglian, GL Holmes… - …, 2023 - Wiley Online Library
How the development and function of neural circuits governing learning and memory are
affected by insults in early life remains poorly understood. The goal of this study was to …

Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration

ML Kloc, DH Marchand, GL Holmes, RD Pressman… - Epilepsy & Behavior, 2022 - Elsevier
Background Febrile seizures are the most common type of seizures in children. While in
most children the outcome is favorable, children with febrile status epilepticus may exhibit …

The neuropsychological presentation of women with epilepsy: Clinical considerations and future directions

SA Lorkiewicz, YA Modiano, BI Miller… - The Clinical …, 2024 - Taylor & Francis
Objective: Cognitive, mood, and behavioral changes are common among persons with
epilepsy (PWE), resulting in a complex neuropsychological presentation. Women with …

Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments

ML Kloc, JM Daglian, GL Holmes, TZ Baram… - …, 2021 - Wiley Online Library
Abstract Objective Febrile seizures (FSs) are the most common form of seizures in children.
Single short FSs are benign, but FSs lasting longer than 30 min, termed febrile status …

Commentary on the Paper “Effect of Seizures on the Developing Brain and Cognition”

GL Holmes - Seminars in pediatric neurology, 2023 - Elsevier
Effect of Seizures on the Developing Brain and Cognition Gregory L. Holmes Seminars in
Pediatric Neurology Volume 23, Issue 2, May 2016, Pages 120–126 Epilepsy is a complex …

Dynamic θ frequency coordination within and between the prefrontal cortex-hippocampus circuit during learning of a spatial avoidance task

CR Dickson, GL Holmes, JM Barry - Eneuro, 2022 - eneuro.org
θ-Scale coordination of prelimbic medial prefrontal cortex (mPFC) local field potentials
(LFPs) and its influence via direct or indirect projections to the ventral hippocampus (vHC) …

[HTML][HTML] Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures

F Velasquez, C Dickson, ML Kloc, CA Schneur… - Neurobiology of …, 2023 - Elsevier
There is increasing human and animal evidence that brain oscillations play a critical role in
the development of spatial cognition. In rat pups, disruption of hippocampal rhythms via …

Sex differences in cholinergic signaling affect functional outcomes for theta–gamma coordination in hippocampal subcircuits following experimental febrile status …

ML Kloc, GL Holmes, JM Barry - Epilepsia, 2024 - Wiley Online Library
Objective Sex determines cognitive outcome in animal models of early life seizure, where
males exhibit impaired hippocampal‐dependent learning and memory compared with …

Early-life seizures alter habit behavior formation and fronto-striatal circuit dynamics

ML Kloc, MG Shultes, RD Pressman, SA Liebman… - Epilepsy & Behavior, 2023 - Elsevier
Obsessive compulsive disorder (OCD) can occur comorbidly with epilepsy; both are
complex, disruptive disorders that lower quality of life. Both OCD and epilepsy are disorders …

Alterations in Rat Hippocampal Glutamatergic System Properties after Prolonged Febrile Seizures

AV Griflyuk, TY Postnikova, SL Malkin… - International Journal of …, 2023 - mdpi.com
Febrile seizures during early childhood may result in central nervous system developmental
disorders. However, the specific mechanisms behind the impact of febrile seizures on the …