COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement …

Y Zhao, Y Yang, M Liu, X Qin, X Yu… - PLOS Neglected …, 2022 - journals.plos.org
Giardia duodenalis, the causative agent of giardiasis, is among the most important causes of
waterborne diarrheal diseases around the world. Giardia infection may persist over …

Inflammatory and pro-resolving lipids in trypanosomatid infections: a key to understanding parasite control

RA López-Muñoz, A Molina-Berríos… - Frontiers in …, 2018 - frontiersin.org
Pathogenic trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei, and Leishmania
spp.) are protozoan parasites that cause neglected diseases affecting millions of people in …

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease

I Carrillo, RAN Rabelo, C Barbosa… - PLoS Neglected …, 2021 - journals.plos.org
Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in
Latin America and is widely distributed worldwide because of migration. In 30% of cases …

Nonsteroidal Anti‐Inflammatory Drugs and Experimental Chagas Disease: An Unsolved Question

ST Nicolau, DP Tres, TS Ayala… - Parasite Immunology, 2024 - Wiley Online Library
Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an
acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is …

Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and …

ACA Pereira, RJ Silva, PS Franco… - Frontiers in …, 2019 - frontiersin.org
Toxoplasma gondii is able to infect a wide range of vertebrates, including humans. Studies
show that cyclooxygenase-2 (COX-2) is a modulator of immune response in multiple types of …

Combination therapy using benznidazole and aspirin during the acute phase of experimental chagas disease prevents cardiovascular dysfunction and decreases …

RS Pereira, AD Malvezi, MI Lovo-Martins… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the main causes of
death due to cardiomyopathy and heart failure in Latin American countries. The treatment of …

Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways

JM Wozniak, TA Silva, D Thomas… - PLoS neglected …, 2020 - journals.plos.org
Chagas disease, the clinical presentation of T. cruzi infection, is a major human health
concern. While the acute phase of Chagas disease is typically asymptomatic and self …

[HTML][HTML] Statin and aspirin use in parasitic infections as a potential therapeutic strategy: A narrative review

V Burgess, JD Maya - Revista Argentina de Microbiología, 2023 - Elsevier
Infections, including zoonoses, constitute a threat to human health due to the spread of
resistant pathogens. These diseases generate an inflammatory response controlled by a …

Beneficial effects of acetylsalicylic acid (aspirin) on the actions of extracellular vesicles shed by Trypanosoma cruzi in macrophages

LF Dos Santos, GF Rodrigues, AD Malvezi… - Parasitology …, 2023 - Elsevier
Trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease, shed
extracellular vesicles (EVs) that promote the susceptibility of host cells to infection. During T …

[HTML][HTML] Uso de estatinas y aspirina en infecciones parasitarias como potencial estrategia terapéutica: Una revisión narrativa

V Burgess, JD Maya - Revista argentina de microbiología, 2023 - SciELO Argentina
Resumen BURGESS, Valentina y MAYA, Juan D.. Statin and aspirin use in parasitic
infections as a potential therapeutic strategy: A narrative review. Rev. argent …