Classical sheep transmissible spongiform encephalopathies: pathogenesis, pathological phenotypes and clinical disease

M Jeffrey, L Gonzalez - Neuropathology and applied …, 2007 - Wiley Online Library
Scrapie is a prion disease or transmissible spongiform encephalopathy (TSE) of sheep,
goats and moufflon. As with its human counterparts, pathology consists of vacuolation …

Progress and limits of PrP gene selection policy

M Dawson, R Moore, S Bishop - Veterinary Research, 2008 - hal.science
Classical scrapie has proved to be a notoriously difficult disease to control due to a poor
understanding of its natural history. The recognition of disease risk linkage to PrP genotype …

Genetics of disease resistance in sheep and goats

SC Bishop, CA Morris - Small ruminant research, 2007 - Elsevier
This review summarises the current state of knowledge of the genetic control of resistance to
infectious and metabolic diseases in small ruminants. Diseases covered include …

Epidemiological and genetical differences between classical and atypical scrapie cases

G Lühken, A Buschmann, H Brandt, M Eiden… - Veterinary …, 2007 - hal.science
The aim of this study was to analyze the epidemiology and prion protein (PrP) genetics in
scrapie-affected sheep flocks in Germany. For this purpose, 224 German scrapie cases in …

Preliminary Observations of Genetic Susceptibility of elk (Cervus Elaphus Nelsoni) to Chronic Wasting Disease by Experimental Oral Inoculation

AN Hamir, T Gidlewski, TR Spraker… - Journal of …, 2006 - journals.sagepub.com
To compare the genetic susceptibility of elk (Cervus elaphus nelsoni) with various alleles of
the PRNP gene, which encodes the normal cellular prion protein, to chronic wasting disease …

Pathogenesis, detection, and control of scrapie in sheep

ED Cassmann, JJ Greenlee - American journal of veterinary …, 2020 - Am Vet Med Assoc
In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a
prion (designated PrP Sc). The normal cellular prion protein (PrP C) is encoded by an …

Evidence of effective scrapie transmission via colostrum and milk in sheep

T Konold, SJ Moore, SJ Bellworthy, LA Terry… - BMC veterinary …, 2013 - Springer
Background Evidence for scrapie transmission from VRQ/VRQ ewes to lambs via milk was
first reported in 2008 but in that study there were concerns that lateral transmission may …

A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig

EM Ibeagha-Awemu, P Kgwatalala, AE Ibeagha… - Mammalian …, 2008 - Springer
Genetic variations through their effects on gene expression and protein function underlie
disease susceptibility in farm animal species. The variations are in the form of single …

Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie

F Houston, W Goldmann, J Foster, L González… - PloS one, 2015 - journals.plos.org
Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to
experimental challenge with various scrapie strains and with bovine spongiform …

Modelling the spread of scrapie in a sheep flock: evidence for increased transmission during lambing seasons

S Touzeau, ME Chase-Topping, L Matthews… - Archives of …, 2006 - Springer
Presence of scrapie infectivity in the placenta suggests the possibility of increased
transmission of scrapie during the lambing season. This hypothesis was explored here …