Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in
transfusional iron overload, strongly indicates that iron accumulation in the heart plays a …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown
reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of …

Sepsis is a known risk factor for new-onset atrial fibrillation (AF), and previous studies have
demonstrated that ferroptosis participates in sepsis-induced organ injury development …

Pacemaker activity of automatic cardiac myocytes controls the heartbeat in everyday life.
Cardiac automaticity is under the control of several neurotransmitters and hormones and is …

Background Obesity is a significant risk factor for atrial fibrillation (AF), and the gut
microbiota is closely related to obesity-induced diseases. However, whether the gut …

Iron is essential for many biological processes. Inadequate or excess amount of body iron
can result in various pathological consequences. The pathological roles of iron in …

Cardiac hemochromatosis or primary iron-overload cardiomyopathy is an important and
potentially preventable cause of heart failure. This is initially characterized by diastolic …

While advanced liver disease was previously considered to be an acquired bleeding
disorder, there is increasing recognition of an associated prothrombotic state with patients …