Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor
(CAR) is rapidly emerging as a promising new treatment for haematological and non …

Acute lymphoblastic leukemia (ALL) is a cancer-specific lymphoid cell. Induction and
consolidation chemotherapy alone or in combination with different therapeutic approaches …

Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …

Background Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized
by immune dysregulation and hyperinflammation. It typically manifests in infancy and is …

Autologous T cells transduced with CD19-directed chimeric antigen receptors have recently
been approved by several regulatory agencies for the treatment of relapsed and refractory …

Understanding of ferritin biology has traditionally centered on its role in iron storage and
homeostasis, with low ferritin levels indicative of deficiency and high levels indicative of …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …

Haemophagocytic syndromes (haemophagocytic lymphohistiocytosis) have a wide range of
causes, symptoms, and outcomes, but all lead to a hyperinflammatory response and organ …