Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

Irritable bowel syndrome (IBS) is an extremely common and often very debilitating chronic
functional gastrointestinal disorder. Despite its prevalence, significant associated healthcare …

In migrating cells, integrin-based focal adhesions (FAs) assemble in protruding lamellipodia
in association with rapid filamentous actin (F-actin) assembly and retrograde flow. How …

The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …

Cells experience mechanical forces throughout their lifetimes. Vinculin is critical for
transmitting these forces, yet how it achieves its distinct functions at cell–cell and cell–matrix …

Background A complex network of putative molecular interactions underlies the architecture
and function of cell-matrix adhesions. Most of these interactions are implicated from …

Abstract The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a
set of computer vision algorithms designed to quantify the behavior of focal adhesions in …

Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical
forces and regulatory signals between the extracellular matrix and an interacting cell. Two …

Background Acute gastroenteritis can precipitate irritable bowel syndrome (IBS) in humans.
Cytolethal distending toxin is common to all pathogens causing gastroenteritis. Its active …

Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating
ligands classically disrupt intramolecular interactions between the vinculin head and tail …