The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Colorectal cancer (CRC) has become a concern because of its high recurrence rate and
metastasis rate, low early diagnosis rate and poor therapeutic effect. At present, various …

Reactive oxygen species are involved in the pathogenesis of cancers and metabolic
diseases, including diabetes, obesity, and fatty liver disease. Thus, inhibiting the generation …

Invasive bladder cancer (BC) is one of the most lethal malignant urological tumors. Although
miR-200a has been reported as an onco-miRNA that targets the PTEN gene in endometrioid …

Bladder cancer is a common malignant tumor of the urinary system. Despite recent
advances in treatments such as local or systemic immunotherapy, chemotherapy, and …

Epithelial mesenchymal transition (EMT) is highly correlated with metastasis during cancer
development. Although previous studies have revealed that ISO is able to inhibit cancer cell …

The regulation of Reactive Oxygen Species (ROS) levels and the contribution therein from
networks regulating cell metabolism, such as autophagy and the mTOR-dependent nutrient …

Bladder cancer (BC) is a potentially life‑threatening malignancy. Due to a high recurrence
rate, frequent surveillance strategies and intravesical drug therapies, BC is considered one …

Background/aims Autophagy is known as a protective intracellular procedure, which can be
regulated by several factors. MiRNA has been suggested as a potential element to mediate …

Sestrin 2, a highly conserved stress-induced protein, participates in the pathological
processes of metabolic and age-related diseases. This p53-inducible protein also regulates …