Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but
predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study …

Some cancer therapies damage DNA and cause mutations in both cancerous and healthy
cells. Therapy-induced mutations may underlie some of the long-term and late side effects of …

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed
whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep …

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Background Despite standard curative-intent treatment with neoadjuvant cisplatin-based
chemotherapy, followed by radical surgery in eligible patients, muscle-invasive urothelial …

Purpose The overall response of cisplatin-based chemotherapy in bladder urothelial
carcinoma (BUC) remains unsatisfactory due to the complex pathological subtypes, genomic …

Despite initial responses,–, most melanoma patients develop resistance to immune
checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor …

The immunotherapeutic treatment of various cancers with an increasing number of immune
checkpoint inhibitors (ICIs) has profoundly improved the clinical management of advanced …