In the last three decades, several flaviviruses of concern that belong to different antigenic
groups have expanded geographically. This has resulted in the presence of often more than …

Flaviviruses pose an increasing threat to global health with their potential to cause severe
disease in millions of people. Protective and long-lived immunity is closely linked to the …

Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South-and
Central America. Like with other flaviviruses, protective immunity is strongly dependent on …

Antigen conformation shapes CD4+ T-cell specificity through mechanisms of antigen
processing, and the consequences for immunity may rival those from conformational effects …

CD4+ T-cell receptors recognize peptide-MHCII complexes displayed on the surface of
antigen-presenting cells to induce an immune response. A fundamental problem in …

West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to
WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense …

In the last three decades, several flaviviruses of concern that belong to different antigenic
groups have expanded geographically. This has resulted in the presence of often more than …

Dengue (DENV) virus and Zika virus (ZIKV) are two flaviviruses of major public health
concern. One drawback designing effective vaccines is our limited understanding of the …

Antigen-presenting cells present peptides derived from foreign pathogens in the form of
peptide-MHCII complexes to induce immune response. Two important and interrelated …

The adaptive immune system plays an important role in protecting us from diseases caused
by pathogens and cancers. An important component of the adaptive immune system is the …