Chemistry, biosynthesis and pharmacology of viniferin: potential resveratrol-derived molecules for new drug discovery, development and therapy
Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized
by plants as a defense mechanism in response to microbial attack, toxins, infections or UV …
by plants as a defense mechanism in response to microbial attack, toxins, infections or UV …
A review of coumarins and coumarin-related compounds for their potential antidiabetic effect
S Ranđelović, R Bipat - Clinical Medicine Insights …, 2021 - journals.sagepub.com
Background and aims: Worldwide, type 2 diabetes mellitus accounts for a considerable
burden of disease, with an estimated global cost of> 800 billion USD annually. For this …
burden of disease, with an estimated global cost of> 800 billion USD annually. For this …
The SARS-CoV-2 transcriptional metabolic signature in lung epithelium
Viruses are efficient metabolic engineers that actively rewire host metabolic pathways to
support their lifecycle. Charting SARS-CoV-2 induced metabolic changes in lung cells could …
support their lifecycle. Charting SARS-CoV-2 induced metabolic changes in lung cells could …
A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives
I Bauer, G Rimbach, S Cordeiro… - Frontiers in …, 2024 - frontiersin.org
Plant extracts are increasingly recognized for their potential in modulating (postprandial)
blood glucose levels. In this context, root extracts are of particular interest due to their high …
blood glucose levels. In this context, root extracts are of particular interest due to their high …
Phytochemicals as regulators of tumor glycolysis and hypoxia signaling pathways: evidence from in vitro studies
The full understanding of the complex nature of cancer still faces many challenges, as
cancers arise not as a result of a single target disruption but rather involving successive …
cancers arise not as a result of a single target disruption but rather involving successive …
[HTML][HTML] Biological potential and therapeutic effectiveness of pteryxin in medicine. A viable alternative to current remedies for the treatment of human disorders
K Patel, DK Patel - Pharmacological Research-Modern Chinese Medicine, 2024 - Elsevier
Abstract Background Herbal medicine, including Chinese herbal medicines is getting
attention in the scientific research due to their long historical applications and reliable …
attention in the scientific research due to their long historical applications and reliable …
Recent developments in ligands and chemical probes targeting solute carrier transporters
A Casiraghi, A Bensimon, G Superti-Furga - Current Opinion in Chemical …, 2021 - Elsevier
Solute carrier (SLC) membrane transporters remain a largely unexploited target class,
despite their central roles in cell identity and metabolism. This gap is reflected in the lack of …
despite their central roles in cell identity and metabolism. This gap is reflected in the lack of …
Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs
MM Mashraqi, N Chaturvedi, Q Alam, S Alshamrani… - Molecules, 2021 - mdpi.com
The Food and Drug Administration (FDA) approved a new class of anti-diabetic medication
(a sodium–glucose co-transporter 2 (SGLT2) inhibitor) in 2013. However, SGLT2 inhibitor …
(a sodium–glucose co-transporter 2 (SGLT2) inhibitor) in 2013. However, SGLT2 inhibitor …
The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA …
Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder caused mainly by
mutations in the MECP2 gene. One of the major RTT features is breathing dysfunction …
mutations in the MECP2 gene. One of the major RTT features is breathing dysfunction …
[PDF][PDF] In-vitro antidiabetic activity of a Bistorta officinalis Delarbre root extract can not be confirmed in the in-vivo models hen's egg test and Drosophila melanogaster.
I Bauer, G Rimbach, S Nevermann… - Journal of Physiology …, 2023 - researchgate.net
The potential of plant bioactives for the prevention and therapy of diabetes is increasingly
being recognized. In the present study we investigated the antidiabetic properties of an …
being recognized. In the present study we investigated the antidiabetic properties of an …