Central and peripheral neuromuscular adaptations to ageing

R Borzuola, A Giombini, G Torre, S Campi… - Journal of clinical …, 2020 - mdpi.com
Ageing is accompanied by a severe muscle function decline presumably caused by
structural and functional adaptations at the central and peripheral level. Although …

Aging and urinary control: Alterations in the brain–bladder axis

CC Hardy, R Korstanje - Aging cell, 2023 - Wiley Online Library
Age‐associated alterations in bladder control affect millions of older adults, with a heavy
burden added to families both economically and in quality of life. Therapeutic options are …

Estimates of persistent inward currents are reduced in upper limb motor units of older adults

AS Hassan, ME Fajardo, M Cummings… - The Journal of …, 2021 - Wiley Online Library
Ageing is a natural process causing alterations in the neuromuscular system, which
contributes to reduced quality of life. Motor unit (MU) contributes to weakness, but the …

Facilitation–inhibition control of motor neuronal persistent inward currents in young and older adults

LBR Orssatto, GL Fernandes… - The Journal of …, 2022 - Wiley Online Library
A well‐coordinated facilitation–inhibition control of motor neuronal persistent inward
currents (PICs) via diffuse neuromodulation and local inhibition is essential to ensure motor …

Decoding the spatiotemporal regulation of transcription factors during human spinal cord development

Y Shi, L Huang, H Dong, M Yang, W Ding, X Zhou, T Lu… - Cell Research, 2024 - nature.com
The spinal cord is a crucial component of the central nervous system that facilitates sensory
processing and motor performance. Despite its importance, the spatiotemporal codes …

Persistent inward currents in human motoneurons: Emerging evidence and future directions

RNO Mesquita, JL Taylor… - Journal of …, 2024 - journals.physiology.org
The manner in which motoneurons respond to excitatory and inhibitory inputs depends
strongly on how their intrinsic properties are influenced by the neuromodulators serotonin …

Comparing natural history of early and late onset pediatric multiple sclerosis

E De Meo, M Filippi, M Trojano, G Comi… - Annals of …, 2022 - Wiley Online Library
Objective This study was undertaken to describe and compare disease course and
prognosis of early (ie, disease onset before age 11 years) and late (ie, disease onset after …

Development of motor circuits: from neuronal stem cells and neuronal diversity to motor circuit assembly

JL Meng, ES Heckscher - Current Topics in Developmental Biology, 2021 - Elsevier
In this review, we discuss motor circuit assembly starting from neuronal stem cells. Until
recently, studies of neuronal stem cells focused on how a relatively small pool of stem cells …

Early movement restriction leads to maladaptive plasticity in the sensorimotor cortex and to movement disorders

M Delcour, M Russier, F Castets, N Turle-Lorenzo… - Scientific reports, 2018 - nature.com
Motor control and body representations in the central nervous system are built, ie, patterned,
during development by sensorimotor experience and somatosensory feedback/reafference …

Age-related modifications of muscle synergies and their temporal activations for overground walking

X Guo, B He, KYS Lau, PPK Chan, R Liu… - … on Neural Systems …, 2022 - ieeexplore.ieee.org
Healthy ageing modifies neuromuscular control of human overground walking. Previous
studies found that ageing changes gait biomechanics, but whether there is concurrent …