Nitrogen-containing heterocyclic rings are common structural components of marketed
drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide …

Recently, quinoline has become an essential heterocyclic compound due to its versatile
applications in the fields of industrial and synthetic organic chemistry. It is a vital scaffold for …

Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

High-intensity transcription and replication supercoil DNA to levels that can impede or halt
these processes. As a potent transcription amplifier and replication accelerator, the proto …

Quinoline is one of the most important and versatile nitrogen heterocycles embodied in
several biologically active molecules. Within the numerous quinolines developed as …

Based on the biologically active heterocycle quinoline, a series (18a-p) of quinoline
hydrazone analogues were prepared, starting from 6-bromo/6-chloro-2-methyl-quinolin-4-yl …

Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …

Inducing necroptosis in cancer cells is an effective approach to circumvent drug‐resistance.
Metal‐based triggers have, however, rarely been reported. Ruthenium (II) complexes …

Abstract A series of (E)-N-2 (5H)-furanonyl sulfonyl hydrazone derivatives have been
rationally designed and efficiently synthesized by one-pot reaction with good yields for the …

In our attempt to develop potential anticancer agents targeting Topoisomerase I (TOP1), two
novel series of 4-alkoxy-2-arylquinolines 14a-p and 19a-c were designed and synthesized …