Corneal nerves in health and disease

MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

Innate immune system activation, inflammation and corneal wound healing

N Fortingo, S Melnyk, SH Sutton, MA Watsky… - International journal of …, 2022 - mdpi.com
Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but
also can predispose an individual to infection. While some inflammation may be beneficial to …

Light-activatable synergistic therapy of drug-resistant bacteria-infected cutaneous chronic wounds and nonhealing keratitis by cupriferous hollow nanoshells

Y Qiao, J He, W Chen, Y Yu, W Li, Z Du, T Xie, Y Ye… - ACS …, 2020 - ACS Publications
Due to the inability to spontaneously heal and vulnerability to bacterial infection, diabetic
patients are frustrated by unexpected epithelium injuries in daily life. Notably, a drug …

Mechanistic investigations of diabetic ocular surface diseases

Q Zhou, L Yang, Q Wang, Y Li, C Wei… - Frontiers in …, 2022 - frontiersin.org
With the global prevalence of diabetes mellitus over recent decades, more patients suffered
from various diabetic complications, including diabetic ocular surface diseases that may …

Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Systemic diseases and the cornea

R Shah, C Amador, K Tormanen, S Ghiam… - Experimental eye …, 2021 - Elsevier
There is a number of systemic diseases affecting the cornea. These include endocrine
disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections …

Influence of diabetes mellitus on anterior segment of the eye

SB Han, HK Yang, JY Hyon - Clinical interventions in aging, 2019 - Taylor & Francis
Diabetes mellitus (DM) has been emerging as one of the most serious health problems
worldwide. Ocular complications of DM are currently one of the major causes of blindness in …

Diabetic keratopathy: Insights and challenges

S Priyadarsini, A Whelchel, S Nicholas, R Sharif… - Survey of …, 2020 - Elsevier
Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most
frequent clinical condition affecting the human cornea, is a potentially sight-threatening …

Photoactivated chromophore for infectious keratitis–Corneal cross-linking (PACK-CXL): A systematic review and meta-analysis

DSJ Ting, C Henein, DG Said, HS Dua - The Ocular Surface, 2019 - Elsevier
Purpose To examine the efficacy of adjuvant photoactivated chromophore for infectious
keratitis–corneal cross-linking (PACK-CXL) for the treatment of infectious keratitis (IK) …

Corneal injury: Clinical and molecular aspects

B Barrientez, SE Nicholas, A Whelchel, R Sharif… - Experimental eye …, 2019 - Elsevier
Currently, over 10 million people worldwide are affected by corneal blindness. Corneal
trauma and disease can cause irreversible distortions to the normal structure and physiology …