Quinoline-based hybrid compounds with antimalarial activity
The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …
Combination therapy strategies for the treatment of malaria
S Alven, B Aderibigbe - Molecules, 2019 - mdpi.com
Malaria is a vector-and blood-borne infection that is responsible for a large number of
deaths around the world. Most of the currently used antimalarial therapeutics suffer from …
deaths around the world. Most of the currently used antimalarial therapeutics suffer from …
Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms
YF Sui, MF Ansari, B Fang, SL Zhang… - European Journal of …, 2021 - Elsevier
An unprecedented amount of fungal and fungal-like infections has recently brought about
some of the most severe die-offs and extinctions due to fungal drug resistance. Aimed to …
some of the most severe die-offs and extinctions due to fungal drug resistance. Aimed to …
Recent developments in the synthesis of hybrid antimalarial drug discovery
BP Raiguru, J Panda, S Mohapatra, S Nayak - Bioorganic Chemistry, 2023 - Elsevier
In this 21 st century, Malaria remains a global burden and causes massive economic trouble
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
Medicinal chemistry updates on quinoline-and endoperoxide-based hybrids with potent antimalarial activity
The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …
pose a challenge to control the disease. The indiscriminate exploitation of the available …
Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove
YN Wang, RRY Bheemanaboina, GX Cai… - Bioorganic & Medicinal …, 2018 - Elsevier
A novel series of purine benzimidazole hybrids were designed and synthesized for the first
time with the aim to circumvent the increasing antibiotic resistance. Hexyl appended hybrid …
time with the aim to circumvent the increasing antibiotic resistance. Hexyl appended hybrid …
Synthesis and antiplasmodial evaluation of 1H-1, 2, 3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues
Abstract A library of 1H-1, 2, 3-triazole-tethered 4-aminoquinoline-benzoxaborole hybrids as
well as aryl substituted benzoxaborole analogues was synthesized and screened for their …
well as aryl substituted benzoxaborole analogues was synthesized and screened for their …
Recent developments of quinoline derivatives and their potential biological activities
M Dib, H Ouchetto, K Ouchetto, A Hafid… - Current Organic …, 2021 - ingentaconnect.com
Heterocyclic compounds containing the quinoline ring play a significant role in organic
synthesis and therapeutic chemistry. Polyfunctionalized quinolines have attracted the …
synthesis and therapeutic chemistry. Polyfunctionalized quinolines have attracted the …
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies
A Rani, A Sharma, J Legac, PJ Rosenthal… - Bioorganic & Medicinal …, 2021 - Elsevier
Quinoline-isoniazid-phthalimide triads have been synthesised to assess their antiplasmodial
efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero …
efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero …