Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

Background Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to
reduce the risk of adverse cardiovascular events in patients with diabetes. Whether …

Background The cardiovascular safety of testosterone-replacement therapy in middle-aged
and older men with hypogonadism has not been determined. Methods In a multicenter …

The American Diabetes Association (ADA)“Standards of Medical Care in Diabetes” includes
the ADA's current clinical practice recommendations and is intended to provide the …

Background This is an overview of the mechanisms of obesity and its relation to
cardiovascular risks, describing the available treatment options to manage this condition …

A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of
cardiovascular diseases (CVD) including coronary heart disease, heart failure …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Although cardiologists have long treated patients with coronary artery disease (CAD) and
concomitant type 2 diabetes mellitus (T2DM), T2DM has traditionally been considered just a …

The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …