Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Translation control is critical to regulate protein expression. By directly adjusting protein
levels, cells can quickly respond to dynamic transitions during stem cell differentiation and …

Many long noncoding RNA (lncRNA) species have been identified in mammalian cells, but
the genomic origin and regulation of these molecules in individual cell types is poorly …

Understanding preimplantation development is important both for basic reproductive biology
and for practical applications including regenerative medicine and livestock breeding …

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To
investigate the age-dependent molecular changes in a mouse model, we compared the …

ATP-dependent chromatin remodeling complexes are a notable group of epigenetic
modifiers that use the energy of ATP hydrolysis to change the structure of chromatin, thereby …

Studies using low-resolution methods to assess gene expression during preimplantation
mouse development indicate that changes in gene expression either precede or occur …

The first wave of transcription, called zygotic genome activation (ZGA), begins during the 2-
cell stage in mouse preimplantation development and marks a vital transition from the …

Background Recent work has revealed that a core group of transcription factors (TFs)
regulates the key characteristics of embryonic stem (ES) cells: pluripotency and self …

The three phases of liver development that are the focus of this review are: the specification
of hepatoblasts within the endoderm, the lineage split of hepatoblasts into hepatocytes and …