Omics in myopia

ET Grochowski, K Pietrowska, T Kowalczyk… - Journal of Clinical …, 2020 - mdpi.com
Myopia is a globally emerging issue, with multiple medical and socio-economic burdens and
no well-established causal treatment thus far. A better insight into altered biochemical …

SWATH based quantitative proteomics reveals significant lipid metabolism in early myopic guinea pig retina

J Bian, YH Sze, DYY Tse, CH To… - International journal of …, 2021 - mdpi.com
Most of the previous myopic animal studies employed a single-candidate approach and
lower resolution proteomics approaches that were difficult to detect minor changes, and …

Comparing SRM and SWATH methods for quantitation of bovine muscle proteomes

W Wu, RT Dai, E Bendixen - Journal of agricultural and food …, 2019 - ACS Publications
Mass spectrometry (MS) has become essential for efficient and accurate quantification of
proteins and proteomes and, thus, a key technology throughout all biosciences. However …

Alteration of retinal metabolism and oxidative stress may implicate myopic eye growth: Evidence from discovery and targeted proteomics in an animal model

FJ Yu, TC Lam, AYH Sze, KK Li, RKM Chun… - Journal of …, 2020 - Elsevier
Myopia, the most common cause of impaired vision, may induce sight-threatening diseases
or ocular complications due to axial elongation. The exact mechanisms underlying myopia …

Sequential window acquisition of all theoretical fragments versus information dependent acquisition for suspected-screening of pharmaceuticals in sediments and …

R Álvarez-Ruiz, Y Picó - Journal of Chromatography A, 2019 - Elsevier
The aquatic ecosystems are dynamic environments often affected directly or indirectly by a
myriad of anthropogenic contaminants that need to be properly identified. In this study, liquid …

Alteration of EIF2 signaling, glycolysis, and dopamine secretion in form-deprived myopia in response to 1% atropine treatment: Evidence from interactive iTRAQ-MS …

Y Zhu, JF Bian, DQ Lu, CH To, CSY Lam… - Frontiers in …, 2022 - frontiersin.org
Purpose: Atropine, a non-selective muscarinic antagonist, effectively slows down myopia
progression in human adolescents and several animal models. However, the underlying …

Retinal neurodegeneration in a mouse model of green-light-induced myopia

S Ji, L Ye, L Zhang, D Xu, J Dai - Experimental Eye Research, 2022 - Elsevier
Purpose To determine the retinal neurodegeneration occurring in mice with green-light-
induced myopia. Methods Four-week-old mice were raised under white or green light (peak …

High-pH reversed-phase fractionated neural retina proteome of normal growing C57BL/6 mouse

YH Sze, Q Zhao, JKW Cheung, KK Li, DYY Tse, CH To… - Scientific data, 2021 - nature.com
The retina is a key sensory tissue composed of multiple layers of cell populations that work
coherently to process and decode visual information. Mass spectrometry-based proteomics …

[HTML][HTML] Identification of Potential Growth-Related Proteins in Chick Vitreous during Emmetropization Using SWATH-MS and Targeted-Based Proteomics (MRMHR)

JKW Cheung, KK Li, L Zhou, CH To… - International Journal of …, 2024 - mdpi.com
The vitreous humor (VH) is a transparent gelatin-like substance that occupies two-thirds of
the eyeball and undergoes the most significant changes during eye elongation. Quantitative …

[HTML][HTML] Data on differentially expressed proteins in retinal emmetropization process in guinea pig using integrated SWATH-based and targeted-based proteomics

SW Shan, DY Tse, B Zuo, C ho To, Q Liu… - Data in brief, 2018 - Elsevier
Myopia is generally regarded as a failure of normal emmetropization process, however, its
underlying molecular mechanisms are unclear. Retinal protein profile changes using …