[HTML][HTML] Recent breakthroughs and future directions in drugging aquaporins

MM Salman, P Kitchen, AJ Yool, RM Bill - Trends in pharmacological …, 2022 - cell.com
Aquaporins facilitate the passive transport of water, solutes, or ions across biological
membranes. They are implicated in diverse pathologies including brain edema following …

Aquaporins: important but elusive drug targets

AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

Plant aquaporins: multifunctional water and solute channels with expanding roles

SD Tyerman, CM Niemietz… - Plant, cell & environment, 2002 - Wiley Online Library
There is strong evidence that aquaporins are central components in plant water relations.
Plant species possess more aquaporin genes than species from other kingdoms. According …

[HTML][HTML] Inhibitors of mammalian aquaporin water channels

M Abir-Awan, P Kitchen, MM Salman… - International journal of …, 2019 - mdpi.com
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in
all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ …

[HTML][HTML] Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Low-Affinity Na+ Uptake in the Halophyte Suaeda maritima

SM Wang, JL Zhang, TJ Flowers - Plant Physiology, 2007 - academic.oup.com
Na+ uptake by plant roots has largely been explored using species that accumulate little
Na+ into their shoots. By way of contrast, the halophyte Suaeda maritima accumulates …

Regulation of brain aquaporins

M Zelenina - Neurochemistry international, 2010 - Elsevier
Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

[HTML][HTML] Mechanisms of aquaporin-facilitated cancer invasion and metastasis

ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …

[HTML][HTML] The central role of aquaporins in the pathophysiology of ischemic stroke

J Vella, C Zammit, G Di Giovanni, R Muscat… - Frontiers in cellular …, 2015 - frontiersin.org
Stroke is a complex and devastating neurological condition with limited treatment options.
Brain edema is a serious complication of stroke. Early edema formation can significantly …

Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site

E Migliati, N Meurice, P DuBois, JS Fang… - Molecular …, 2009 - ASPET
Aquaporin (AQP) water channels, essential for fluid homeostasis, are expressed in
perivascular brain end-feet regions of astroglia (AQP4) and in choroid plexus (AQP1). At a …