Patients with advanced or recurrent cervical cancer have poor prognosis, and their 1-year
survival is only 10%–20%. Chemotherapy is considered as the standard treatment for …

Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of
malignancies in women worldwide. Cisplatin is one of the widely used drugs for the …

A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

The epidermal growth factor receptor (EGFR) is upregulated in numerous human cancers.
Inhibition of EGFR signaling induces autophagy in tumor cells. Here, we report an …

Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is
activated downstream of growth factors, energy signalling and intracellular essential amino …

Deconvolution of regulatory mechanisms that drive transcriptional programs in cancer cells
is key to understanding tumor biology. Herein, we present matched transcriptome (scRNA …

Hepatocellular carcinoma (HCC) is a hypervascular cancer characterized by rapid
progression as well as resistance to conventional chemotherapy. It has been shown that …

Aberrant activation or disruption of autophagy promotes tumorigenesis in various preclinical
models of cancer, but whether the autophagy pathway is a target for recurrent molecular …

Cancer as one of the leading causes of human deaths has always been one of the main
health challenges in the world. Despite recent advances in therapeutic and diagnostic …