The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

Chemotherapy-induced neuropathy (CIN) is a major dose-limiting side effect of anticancer
therapy that can compel therapy discontinuation. Inadequate analgesic efficacy of current …

Despite rapid advances in the field of chronic pain, it remains extremely challenging in the
clinic. Pain treatment strategies have not improved for decades as opioids remain the main …

Enhancing neuronal α7 nicotinic acetylcholine receptor (α7 nAChR) function can alleviate
cognitive deficits. Here, we report the design, synthesis, and evaluation of N-(4 …

Background and Purpose Positive allosteric modulators of the α7 nicotinic acetylcholine
(nACh) receptor (α7‐PAMs) possess promnesic and procognitive properties and have …

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of cancer treatment,
often linked with pain complaints. Patients report mechanical and thermal hypersensitivity …

Clinical intervention of pain is often accompanied by changes in affective behaviors, so both
assays of affective and sensorial aspects of nociception play an important role in the …

The aim of this study is to determine whether type I and type II positive allosteric modulators
(PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) induce antidepressant-like activity …

Neuropathic pain affects about 7–8% of the population, and its management still poses
challenges with unmet needs. Over the past decades, researchers have explored the …