Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue
homeostasis by regulating cytokine production, cell survival, and cell death. However, how …

Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …

Regulated cell death pathways have important functions in host defense and tissue
homeostasis. Studies in genetic mouse models provided evidence that cell death could …

Cytokines released from innate immune cells play key roles in the regulation of the immune
response. These intercellular messengers are the source of soluble regulatory signals that …

Abstract Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced
in epithelia by bacterial challenge and inflammatory stimuli. Here we show that IL-17C …

Abstract Tumor Necrosis Factor (TNF) is a potent inflammatory cytokine that exerts its
functions through the activation of two distinct receptors, TNFR1 and TNFR2. Both receptors …

Extracellular vesicles are membranous structures shed by almost every living cell. Bacterial
gram-negative outer membrane vesicles (OMVs) and gram-positive membrane vesicles …

OBJECTIVE The metabolic syndrome (MetS) is highly prevalent and confers an increased
risk for diabetes and cardiovascular disease (CVD). While MetS is a proinflammatory state …

Nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK) activation play
central roles in the induction of gene expression in innate immune cells following pathogen …

Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in
the Caucasian population. Tumor necrosis factor (TNF) plays an essential role in the …