The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells

A Kulesza, L Paczek, A Burdzinska - Biomedicines, 2023 - mdpi.com
The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

PGE2 produced by exogenous MSCs promotes immunoregulation in ARDS induced by highly pathogenic influenza a through activation of the wnt-β-catenin signaling …

R Yudhawati, K Shimizu - International Journal of Molecular Sciences, 2023 - mdpi.com
Acute respiratory distress syndrome is an acute respiratory failure caused by cytokine
storms; highly pathogenic influenza A virus infection can induce cytokine storms. The innate …

Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks

PS Couto, DJ Stibbs, MC Rotondi, Y Takeuchi… - Applied Microbiology …, 2023 - Springer
Due to their immunomodulatory properties and in vitro differentiation ability, human
mesenchymal stromal cells (hMSCs) have been investigated in more than 1000 clinical trials …

Labeling and tracking of individual human mesenchymal stromal cells using photoconvertible fluorescent microcapsules

OA Sindeeva, PA Demina, ZV Kozyreva… - International Journal of …, 2023 - mdpi.com
The behavior and migration of human mesenchymal stromal cells (hMSCs) are focal points
of research in the biomedical field. One of the major aspects is potential therapy using …

Clinical benefit of autologous platelet-rich plasma infusion in ovarian function rejuvenation: evidence from a before-after prospective pilot study

A Garavelas, P Mallis, E Michalopoulos, E Nikitos - Medicines, 2023 - mdpi.com
Background: The intraovarian administration of autologous platelet-rich plasma (PRP) acts
beneficially for the stimulation of follicle production in women presenting different forms of …

[HTML][HTML] Single mesenchymal stromal cell migration tracking into glioblastoma using photoconvertible vesicles

OA Sindeeva, PA Demina, ZV Kozyreva… - Nanomaterials, 2024 - mdpi.com
Reliable cell labeling and tracking techniques are imperative for elucidating the intricate and
ambiguous interactions between mesenchymal stromal cells (MSCs) and tumors. Here, we …

Dysregulated balance in Th17/Treg axis of Pristane-induced lupus mouse model, are mesenchymal stem cells therapeutic?

A Hoseinzadeh, Z Rezaieyazdi, M Mahmoudi… - International …, 2023 - Elsevier
Background Despite advances in general and targeted immunosuppressive therapies,
limiting all mainstay treatment options in refractory systemic lupus erythematosus (SLE) …

3D Porous Polymer Scaffold-Conjugated KGF-Mimetic Peptide Promotes Functional Skin Regeneration in Chronic Diabetic Wounds

S Choudhury, M Madhu Krishna, D Sen… - … Applied Materials & …, 2024 - ACS Publications
The re-epithelialization process gets severely dysregulated in chronic nonhealing diabetic
foot ulcers/wounds. Keratinocyte growth factor (KGF or FGF-7) is the major modulator of the …

Modified nanofat grafting: Stromal vascular fraction simple and efficient mechanical isolation technique and perspectives in clinical recellularization applications

P Girard, J Dulong, J Duisit, C Mocquard… - … in Bioengineering and …, 2022 - frontiersin.org
Background: Nanofat grafting (NG) is a simple and cost-effective method of lipoaspirates
with inter-syringe passages, to produce stromal vascular fraction (SVF) and isolate adipose …

Comparison of Cost and Potency of Human Mesenchymal Stromal Cell Conditioned Medium Derived from 2-and 3-Dimensional Cultures

M Madrigal, PL Fernández, R Lleonart, L Carreño… - Bioengineering, 2023 - mdpi.com
Mesenchymal stromal cell (MSC)-derived products, such as trophic factors (MTFs), have anti-
inflammatory properties that make them attractive for cell-free treatment. Three-dimensional …