The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted
homeostatic regulator, which influences a wide-variety of physiological processes all over …

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high
shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells …

The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Skin photoaging is mainly induced by ultraviolet (UV) irradiation and its manifestations
include dry skin, coarse wrinkle, irregular pigmentation, and loss of skin elasticity. Dietary …

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …

Phenotypic polarization of macrophages is deemed essential in innate immunity and various
pathophysiological conditions. We have now determined key aspects of the molecular …

Myocardial interstitial fibrosis (MIF) is a common finding in heart failure (HF) patients, both
with preserved and reduced ejection fraction, as well as in HF animal models. MIF is …

Implantation of biomaterials or devices into soft tissue often leads to the development of the
foreign body response (FBR), an inflammatory condition that can cause implant failure …